Or vice versa! Maybe you already have the chordal harmony, but are looking to see if playing a lead line over in a phrygian-dominant mode is appropriate.
The phrygian-dominant scale is a mode based off of starting from the fifth degree of the harmonic minor scale. So, to remind, a harmonic minor scale looks as such:

And if you were to start from the fifth degree, it would not look like this, becoming the phrygian-dominant scale:

Notice that the scale degrees are | 1 b2 3 4 5 b6 b7 1 | and what chords can be derived from them. The strongest chords built when playing in this mode are:

Harmonic movements between I – bII , and I – bvii are good indicators to the ear that you have now dove into the world of phrygian-dominant.
In the case that you are in a regular major/minor kay, but want to incorporate the phrygian-dominant, look to add chords like: 7alt , 7(b9b13) , V7/III , and V7/VI . These best fit the pitch collection of the mode. Also, a VImaj7 chord can possibly work if the melody has a raised sixth being approached from above.
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